Timothy Hla Selected Research

Sphingosine-1-Phosphate Receptors

1/2022	Endothelial-Specific Loss of Sphingosine-1-Phosphate Receptor 1 Increases Vascular Permeability and Exacerbates Bleomycin-induced Pulmonary Fibrosis.
1/2022	Sphingosine 1-phosphate receptor-targeted therapeutics in rheumatic diseases.
1/2021	Endothelial S1P1 Signaling Counteracts Infarct Expansion in Ischemic Stroke.
12/2019	Myeloid sphingosine-1-phosphate receptor 1 is important for CNS autoimmunity and neuroinflammation.
1/2019	Sphingosine 1-phosphate and inflammation.
1/2019	Upregulation of sphingosine-1-phosphate receptor 3 on fibroblast-like synoviocytes is associated with the development of collagen-induced arthritis via increased interleukin-6 production.
11/2018	Sphingosine 1-Phosphate Receptor 1 Signaling Maintains Endothelial Cell Barrier Function and Protects Against Immune Complex-Induced Vascular Injury.
4/2015	Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy.
12/2014	Individual variation of human S1P₁ coding sequence leads to heterogeneity in receptor function and drug interactions.
11/2014	Cardiac and vascular effects of fingolimod: mechanistic basis and clinical implications.

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Timothy Hla Research Topics

Disease

27	Neoplasms (Cancer) 01/2022 - 01/2002
25	Inflammation (Inflammations) 01/2022 - 07/2003
12	Multiple Sclerosis 01/2019 - 04/2009
11	Breast Neoplasms (Breast Cancer) 01/2020 - 01/2003
9	Carcinogenesis 09/2014 - 07/2003
7	Neuroinflammatory Diseases 12/2019 - 06/2011
6	Vascular Diseases (Vascular Disease) 01/2022 - 08/2002
6	Fibrosis (Cirrhosis) 01/2020 - 10/2008
6	Pathologic Neovascularization 01/2019 - 04/2003
4	Atherosclerosis 01/2020 - 01/2008
4	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 12/2019 - 11/2013
4	Relapsing-Remitting Multiple Sclerosis 01/2019 - 01/2012
4	Rheumatoid Arthritis 01/2019 - 08/2006
4	Neuroblastoma 09/2015 - 08/2011
4	Hypoxia (Hypoxemia) 08/2011 - 11/2003
3	Obesity 01/2022 - 03/2011
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 04/2004
3	Hypertension (High Blood Pressure) 01/2021 - 09/2015
3	Neoplasm Metastasis (Metastasis) 11/2020 - 10/2008
3	Hyperplasia 12/2015 - 06/2005
3	Pain (Aches) 10/2013 - 09/2004
3	Wilms Tumor (Wilm's Tumor) 04/2009 - 10/2008
2	Autoimmune Diseases (Autoimmune Disease) 01/2022 - 12/2014
2	Hemorrhage 01/2022 - 03/2013
2	Experimental Arthritis 01/2019 - 08/2006
2	Arthritis (Polyarthritis) 01/2019 - 08/2006
2	Ureteral Obstruction 01/2018 - 05/2014
2	Glioblastoma (Glioblastoma Multiforme) 09/2015 - 05/2005
2	Lymphopenia (Lymphocytopenia) 06/2011 - 07/2010
2	Atherosclerotic Plaque (Atheroma) 01/2011 - 01/2008
2	Colonic Neoplasms (Colon Cancer) 03/2003 - 01/2003
1	Shock 01/2022
1	Hemorrhagic Shock 01/2022
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2022
1	Rheumatic Diseases (Rheumatism) 01/2022
1	Hemorrhagic Stroke 01/2021
1	Ischemic Stroke 01/2021
1	Brain Injuries (Brain Injury) 01/2021
1	Demyelinating Diseases (Demyelinating Disease) 01/2019

Drug/Important Bio-Agent (IBA)

23	Sphingosine-1-Phosphate ReceptorsIBA 01/2022 - 04/2004
19	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 01/2022 - 10/2004
16	Fingolimod Hydrochloride (FTY720)FDA Link 01/2021 - 11/2003
10	LipidsIBA 01/2020 - 01/2008
10	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 04/2009 - 03/2003
9	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 10/2013 - 01/2002
7	Proteins (Proteins, Gene)FDA Link 01/2020 - 03/2003
6	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2018 - 04/2003
6	Messenger RNA (mRNA)IBA 12/2014 - 01/2003
6	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 12/2014 - 01/2004
6	ProstaglandinsIBA 04/2009 - 01/2002
5	Aromatase (CYP19)IBA 01/2022 - 05/2006
5	LigandsIBA 01/2022 - 01/2002
5	SphingosineIBA 01/2019 - 08/2006
5	sphingosine kinaseIBA 01/2018 - 08/2006
4	Phosphotransferases (Kinase)IBA 12/2015 - 10/2004
4	SphingolipidsIBA 11/2014 - 08/2011
3	CytokinesIBA 01/2019 - 01/2011
3	Pharmaceutical PreparationsIBA 01/2019 - 09/2013
3	Apolipoproteins E (ApoE)IBA 08/2015 - 01/2008
3	Estrogens (Estrogen)FDA Link 03/2011 - 05/2006
3	Hormones (Hormone)IBA 03/2011 - 05/2006
3	Small Interfering RNA (siRNA)IBA 04/2009 - 11/2003
3	Prostaglandins EIBA 02/2008 - 01/2004
3	Dinoprostone (PGE2)FDA Link 11/2005 - 05/2005
3	EnzymesIBA 05/2005 - 07/2003
2	Bleomycin (Blenoxane)FDA LinkGeneric 01/2022 - 01/2014
2	LysophospholipidsIBA 01/2022 - 01/2021
2	HDL LipoproteinsIBA 01/2020 - 08/2017
2	Interleukin-6 (Interleukin 6)IBA 12/2019 - 01/2019
2	Interleukin-17 (Interleukin 17)IBA 01/2019 - 11/2013
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2019 - 05/2005
2	EicosanoidsIBA 12/2018 - 06/2005
2	Angiotensin IIIBA 01/2017 - 09/2015
2	TNF Receptor-Associated Factor 2 (TRAF2)IBA 01/2017 - 12/2015
2	MicroRNAs (MicroRNA)IBA 11/2015 - 05/2014
2	JTE 013IBA 09/2015 - 08/2011
2	Angiogenesis Inducing Agents (Angiogenesis Factor)IBA 05/2014 - 08/2011
2	Phosphates (Orthophosphate)IBA 11/2013 - 02/2011
2	Biological ProductsIBA 11/2012 - 04/2004
2	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 04/2009 - 01/2002
2	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 09/2007 - 05/2005
2	Peptides (Polypeptides)IBA 08/2006 - 10/2004
2	Celecoxib (Celebrex)FDA Link 05/2005 - 01/2004
2	leptomycin BIBA 11/2003 - 01/2003
2	PPAR gammaIBA 08/2002 - 01/2002
1	Thrombin FDA Link 01/2022
1	lysophosphatidic acidIBA 01/2021
1	CholesterolIBA 01/2020
1	Toll-Like Receptor 4IBA 01/2020
1	LDL Receptors (LDL Receptor)IBA 01/2020
1	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 01/2020
1	CollagenIBA 01/2019
1	Immunomodulating AgentsIBA 01/2019
1	ChemokinesIBA 01/2019
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2019
1	GlycolipidsIBA 01/2019
1	Galactosylceramides (Galactocerebrosides)IBA 01/2019

Therapy/Procedure

9	Therapeutics 01/2022 - 01/2002
1	Resuscitation 01/2022
1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/2020